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Prior COVID-19, the World Health Organization (WHO) reported that less than 50% of the world's population was able to obtain essential health services. These numbers have decreased with the onset of the pandemic. Concurrently, the pandemic has amplified the gaps in access and extended inequality in African contexts. This requires a concerted effort to reimagine and rebuild Africa's healthcare system to inclusively attend to the needs of society's most vulnerable populations. Women in leadership provide an opportunity to do this. Through the advancement of strategic leadership development focused on women and girls, developing African healthcare contexts have the potential to aid in the eradication of endemics like gender-based violence, extend community sustainability, and elevate the collective consciousness for women, girls, and other marginalized populations. Through this chapter, the authors present a compelling and holistic conceptual model and the accompanying practice grounded in transformational and adaptive leadership, systems thinking, and strategic social influence that creates the foundation for the development of women in leadership to advance developing African healthcare contexts. The implications for this emergent strategy advance the field of leadership calling for applied leadership within African healthcare contexts, advance society through a coordinated and integrated approach to healthcare service and patient care, and create direct linkages to the UN Sustainable Development Goal (SDG) 3 – Good Health and Well-being, SDG 5 – Gender Equality, SDG 10 – Reduce Inequalities, and SDG 11 – Sustainable Cities and Communities, while advancing our collective global community.

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